Figure 1. Functional recovery of the infarcted heart is enhanced by the loss of E2F2 expression and impaired by the loss of endothelial E2F3 expression.
MI was surgically induced in VE-Cre; E2F3fl/fl and E2F2 KO mice and their WT littermates, VE-Cre; E2F3+/+ and E2F2 WT, respectively, and the heart function was assessed with echocardiography at the indicated time points for (A) LV ejection fraction, (B) fractional shortening, (C) end-systolic and (D) end-diastolic volumes. n = 12 mice per group. *P<0.05 vs. VE-Cre; E2F3+/+, #P<0.05 vs. E2F2 WT.