Table 2. Differentially methylated CpGs in European American (EA) alcoholics and healthy controls who were exposed to childhood adversity (CA).

CpG site	Genes	EA alcoholics (N = 136)			EA healthy controls (N = 103)			All EA subjects (N = 239)
		β +CAa	β −CAb	Padj	β +CAa	β −CAb	Padj	β +CAa	β −CAb	Padj c
cg17108064	CHRNA5	0.063	0.053	0.003	0.068	0.047	0.001	0.064	0.05	0.00002d
cg06031989	HTR1B	0.047	0.040	0.008	0.056	0.04	0.0005	0.048	0.04	0.00009d
cg12216825	HTR1B	0.015	0.012	0.004	0.015	0.011	0.021	0.015	0.011	0.0002
cg08354950	CART	0.024	0.019	0.007	0.025	0.019	0.042	0.024	0.019	0.0005
cg00314411	OPRL1	0.137	0.121	0.012	0.158	0.126	0.026	0.139	0.123	0.0009
cg12215457	HTR1B	0.09	0.084	0.009	0.094	0.082	0.046	0.091	0.083	0.001
cg12902246	RGS19	0.185	0.172	0.020	0.197	0.171	0.037	0.187	0.171	0.002
cg16206611	ALDH1A1	0.079	0.072	0.031	0.094	0.071	0.015	0.081	0.071	0.002
cg24377504	OPRL1	0.038	0.033	0.042	0.04	0.031	0.022	0.038	0.032	0.004
cg08754521	PENK	0.023	0.017	0.028	0.026	0.017	0.022	0.023	0.017	0.004

^aMethylation levels (β) of CpGs in subjects who were exposed to childhood adversity (+CA).

^bMethylation levels (β) of CpGs in subjects who were not exposed to childhood adversity (−CA).

^c P_adj was the adjusted P value calculated using multivariate linear regression analysis with adjustment of sex, age, ancestry proportion.

^d P_adj survived Bonferroni corrections.