Table 3. Differentially methylated promoter regions of genes in both European American (EA) alcoholics and healthy controls who were exposed to childhood adversity (CA).

Genes	EA alcoholics (n = 136)			EA healthy controls (n = 103)			All EA subjects (n = 239)
	PC1	PC1	Padj c	PC1	PC1	Padj c	PC1	PC1	Padj c
	(+CA)a	(−CA)b		(+CA)a	(−CA)b		(+CA)a	(−CA)b
OPRL1	0.011	−0.006	0.010	0.031	−0.003	0.021	0.013	−0.005	0.0006
ALDH1A1	0.005	−0.002	0.025	0.020	−0.003	0.038	0.007	−0.002	0.004
RGS19	0.011	−0.004	0.011	0.021	−0.004	0.049	0.012	−0.004	0.001

^aPrincipal component 1 (PC1) in subjects with childhood adversity (+CA).

^bPrincipal component 1 (PC1) in subjects without childhood adversity (−CA).

^c P _adj was calculated using multivariate linear regression analysis with adjustment of sex, age, ancestry proportion.