Figure 1.
Western blots (a) of candidate proteins implicated in resistance to platinum-based chemotherapy. The cell lines are presented on the top and the individual proteins on the right with ACTB (actin) as an internal control. Western blots (b) of the five cell lines where knockdowns were prepared to GTPπ including Toledo, 3008, 2262, 2289 and CEM. The 50% inhibitory concentration (IC50, μM) of the cells and their GTPπ knockdowns to the different drugs (oxaliplatin (c), cisplatin (d) and adriamycin (e)) are presented in bar diagrams. The data is expressed as the mean ± standard deviation.
