Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Stem Cell Rev. 2013 Jun;9(3):360–372. doi: 10.1007/s12015-013-9433-8

Figure 7.

Figure 7

Diet-induced diabetes (DIDM) impairs recovery from hindlimb ischemia, induces adipocyte differentiation in ischemic muscle, and restricts MSC multipotency. (A) Foot blood flow recovery in DIDM mice (mean±SEM, n=6; *P<0.05 vs. DIDM; note that the WT data shown here were generated specifically for comparison to DIDM mice and are different from those displayed in Figure 3). (B) Intramuscular adipocyte infiltration within the ischemic hindlimb muscle from DIDM mice. (C) Oxidant levels, as evidenced by DCF staining (n=7). (D) MSCs from DIDM demonstrated increased differentiation to an adipocyte phenotype (n=8). (E) MSCs from DIDM mice demonstrated reduced differentiation to an endothelial phenotype (n=7–8). (For panels C–E: mean±SEM; *P<0.05.). Reprinted with permission from JAHA with the specific citation[43].