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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):e101–e108. doi: 10.1097/QAI.0b013e31828e1e56

Figure 1.

Figure 1

Sensitivity analysis based on increasing proportions of lumbar punctures (LP) performed in persons with suspected meningitis, who do not have meningitis (i.e. negative LP). As the proportion of negative LPs increase, the cost per diagnostic evaluation changes differently for each regimen. For the comprehensive strategy, where every test is performed, there is a direct 1:1 linear increase in costs per each meningitis diagnosis. For the minimalist and stepwise strategies, the diagnostic algorithms stop after the first two and three tests are negative, respectively. Thus as the proportion of normal LPs approach 50%, the additional cost per meningitis diagnosis is $2.78, $7.08, and $16.00 for the minimalist, stepwise, and comprehensive strategies over the base model.