Table 3.

Costs and Effectiveness by Diagnostic Strategy with Disease Prevalence in Uganda

Diagnostic Strategy	Prevalence of Disease	% Correct Diagnosis	Cost per Person
MINIMALIST STRATEGY	-	91.1%	$6.17
Bacterial Meningitis	4%	70.0%	$9.50
Tuberculosis Meningitis	8%	22.4%	$11.84
Cryptococcal Meningitis	59%	99.0%	$2.53
Other	32%	97.3%	$11.66
STEPWISE STRATEGY	-	93.8%	$9.72
Bacterial Meningitis	4%	90.0%	$10.89
Tuberculosis Meningitis	8%	51.5%	$22.75
Cryptococcal Meningitis	59%	98.4%	$5.93
Other	32%	96.7%	$13.70
COMPREHENSIVE STRATEGY	-	93.3%	$32.00
Bacterial Meningitis	4%	99.0%*	$32.00
Tuberculosis Meningitis	8%	30.0%*	$32.00
Cryptococcal Meningitis	59%	99.0%	$32.00
Other	32%	98.9%	$32.00

^*Assumption: testing performed prior to the administration of antibiotics with increasing diagnostic yield by inclusion of bacterial culture in the comprehensive approach as well as a large volume CSF collection >6mL for AFB stain.