Table 1.
Diagnostic accuracy of coronary artery calcium using multidetector computed tomography for the detection of obstructive coronary artery disease in symptomatic patients
| Author, Year [Ref] | n | Study Type and Population | Scanner/Slice Thickness | Men (%) | Mean age | CAC Prevalence n (%) | Confirmed By ICA | Prevalence ≥50% stenosis | NPV% | LR(−) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAC = 0 | CAC > 0 | CAC = 0 | CAC > 0 | |||||||||
| Haberl et al. 2005 [38] | 133 | Prospective observational; chest pain referred for ICA | MDCT/1.3 mm | 62 | 67 | 25 (19) | 108 (81) | Yes | 8 (32) | 45 (42) | 68 | 0.71 |
| Henneman et al. 2008 [39] | 40 | Prospective, observational; ED patients referred for ICA | MDCT | 65 | 57 | 13 (33) | 28 (67) | Yes | 5 (38) | 21 (78) | 66 | 0.36 |
| Akram et al. 2008 [35] | 134 | Retrospective; referred for ICA and CCTA | MDCT/0.6 mm | 47 | 57 | 49 (64) | 85 (63) | Yes | 4 (8) | 24 (28) | 92 | 0.34 |
| Gottlieb et al. 2010 [37] | 291 | Prospective, randomized; referred for ICA | MDCT/0.6 mm | 73 | 59 | 72 (25) | 219 (75) | Yes | 14 (19) | 149 (68) | 81 | 0.19 |
| Fernandez et al. 2011 [36] | 225 | Retrospective; ED patients | 64 MDCT/0.6mm | 45 | 53 | 133(59) | 92(41) | No (CCTA only) | 2 (1.5) | 18 (20) | 99 | 0.16 |
| Villines et al. 2012 [34] | 10,037 | Prospective observational registry; referred for CCTA | ≥64 MDCT | 56 | 57 | 5128 (51) | 4909 (49) | No (CCTA only) | 180 (3.5) | 1423 (29) | 96 | 0.19 |
| Yoon et al. 2012 [41] | 136 | Prospective observational; ED patients | MDCT/0.6 mm | 58 | 56 | 92 (68) | 44 (32) | No (CCTA only) | 14 (15) | 28 (64) | 85 | 0.4 |
| Von Ziegler et al. 2012 [40] | 351 | Retrospective; referred for ICA | MDCT or DSCT/0.6 mm | 68 | 61 | 67 (19) | 284 (81) | Yes | 1 (1.5) | 132 (47) | 99 | 0.02 |
CAC, coronary artery calcium; CCTA, coronary computed tomography angiography; DSCT, dual source computed tomography; ED, emergency department; ICA, invasive coronary angiography; LR(−), negative likelihood ratio; MDCT, multidetector computed tomography; NPV, negative predictive value