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. 2013 Mar 22;3(3):249–262. doi: 10.1002/brb3.115

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© 2013 Published by Wiley Periodicals, Inc.

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(A–D) Nonlinear interactions between treatment (Off-, On-apomorphine), striatal response during low-, medium-, high-load working memory, and dopamine transporter (DAT)-BP_ND values in patients with Parkinson's disease (PD). In PD-Off, the relation between the striatal BOLD activity and DAT-BP_ND values follows a U-shaped model; in contrast, the same relation follows an inverted-U shape model in PD-On. The color bars represent T statistics. For display purposes, maps are thresholded at P < 0.005, uncorrected, but results are significant at P < 0.05, family-wise error (FWE), small volume correction (svc). Coordinates (x, y, and z) are in the Montreal Neurological Institute (MNI) space. BOLD, blood oxygenated level dependent; A.U., arbitrary unit; R, right hemisphere.