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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Neuron. 2013 Mar 14;78(1):65–80. doi: 10.1016/j.neuron.2013.02.029

Figure 4. VCP recruitment to mitochondria in primary neurons is Parkin-dependent.

Figure 4

Primary neurons were transfected with mito-dsRED and VCP-EGFP and treated with DMSO or CCCP for 48 hrs. VCP-EGFP signal remained diffuse with some accumulation in Golgi in neurons treated with DMSO, but relocalized to mitochondria in neurons treated with CCCP. This relocalization was abolished by knockdown of endogenous Parkin by siRNA.