Table 1.
Clinical arguments for the immunoediting hypothesis in epithelial ovarian carcinoma
| Authors | Year | Findings |
|---|---|---|
|
Spontaneous anti-tumor response | ||
| Zhang L et al. [21] |
2003 |
Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival |
| Raspollini NR et al. [22] |
2005 |
Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival (plus chemotherapeutic response) |
| Sato E et al. [23] |
2005 |
Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival |
| Hamanishi J et al. [24] |
2007 |
Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival |
| Clarke B et al. [25] |
2008 |
Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival (only for high grade serous EOC, but not for endometrioïd or mucinous EOC) |
| Shah CA et al. [26] |
2008 |
Association between intraepithelial T-cell infiltration (TIL CD8+) and optimal debulking surgery |
| Tomsova M et al. [27] |
2008 |
Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival |
| Callahan MJ et al. [38] |
2008 |
Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival |
| Han LY et al. [28] |
2008 |
Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
| Stumpf M et al. [29] |
2009 |
Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
| Leffers N et al. [30,39] |
2009 |
Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival |
| Milne K et al. [31] |
2009 |
Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
| Adams SF et al. [32] |
2009 |
Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
| Kryczek I et al. [35] |
2009 |
Association between intraepithelial T-cell infiltration (TIL CD4+ with IL-17 secretion) and patient survival |
|
Tumor immune evasion | ||
| Curiel TJ et al. [36] |
2004 |
Inverse association between survival and intratumoral regulatory T cells (CD4+CD25+FoxP3+) |
| Wolf D et al. [40] |
2005 |
Inverse association between survival and intratumoral regulatory T cells (FoxP3+) |
| Dong HP et al. [41] |
2006 |
Inverse association between survival and intratumoral NK (CD3- CD16+) or B cells (CD19+) |
| Kryczek I et al. [42] |
2007 |
Inverse association between survival and intratumoral B7-H4+ macrophage or regulatory T cells (FoxP3+) |
| Hamanishi J et al. [24] |
2007 |
PD-L1 expression by tumor predicts low T-cell infiltration |
| Buckanovitch RJ et al. [43] |
2008 |
Endothelin B receptor (ETBR) expression restricts T-cell infiltration and predicts poor survival |
| Labidi-Galy SI [44,45] | 2011 | Inverse association between survival and intratumoral pDC (CD4+, CD123+, BDCA2+) |
PD-1: programmed cell death 1; PD-L1: PD-1 ligand 1; ETBR: endothelin B receptor; pDC: plasmacytoïd dendritic cells.