Table 1.

Selected characteristics of women participating in The EDGE Study.

Characteristic	Cases (n=417) n (%)	Controls (n=395) n (%)	p value	Age-Adjusted OR (95% CI)
Education
High school or less	154 (36.9)	134 (33.9)	0.06	1.00
College	183 (43.9)	158 (40.0)		0.92 (0.66–1.27)
Graduate school	80 (19.2)	103 (26.1)		0.60 (0.41–0.88)
Race/Ethnicity
White	355 (85.3)	349 (88.8)	0.04	1.00
Black	36 (8.7)	17 (4.3)		1.96 (1.08–3.57)
Other	10 (2.4)	16 (4.1)		0.54 (0.24–1.21)
Hispanic (any race)	15 (3.6)	11 (2.8)		1.14 (0.51–2.54)
Parity
0–1	147 (35.3)	92 (23.3)	<0.01	1.00
2	142 (34.1)	140 (35.4)		0.64 (0.45–0.90)
≥3	128 (30.7)	163 (41.3)		0.53 (0.37–0.76)
Oral Contraceptive Use
Never	224 (53.7)	199 (50.4)	0.34	1.00
Ever	193 (46.3)	196 (49.6)		0.69 (0.51–0.93)
HRT Use
Never	335 (80.3)	291 (73.7)	0.02	1.00
Unopposed E only	34 (8.2)	31 (7.9)		0.97 (0.58–1.63)
Any combined HRT	48 (11.5)	73 (18.5)		0.54 (0.36–0.81)
Age at Menarche
>13	74 (17.8)	102 (25.9)	0.02	0.66 (0.46–0.95)
12–13	233 (56.0)	198 (50.3)		1.00
≤11	109 (26.2)	94 (23.9)		0.93 (0.66–1.31)
Menopause
Premenopausal	59 (14.2)	48 (12.2)	0.92
Postmenopausal	358 (85.9)	347 (87.9)
Age at menopause
<40	13 (3.1)	12 (3.0)		0.97 (0.43–2.21)
41–54	254 (60.9)	243 (61.5)		1.00
≥55	41 (9.8)	39 (9.9)		1.11 (0.68–1.80)
Unknown	50 (12.0)	53 (13.4)		0.91 (0.59–1.40)
BMI
Normal (<25)	105 (25.2)	189 (47.9)	<0.01	1.00
Overweight (25–29.9)	121 (29.0)	119 (30.1)		1.93 (1.36–2.75)
Obese (30–34.9)	68 (16.3)	62 (15.7)		2.02 (1.32–3.08)
Very obese (≥35)	123 (29.5)	25 (6.3)		8.47 (5.16–13.89)
Smoking status			0.24
Never	231 (55.4)	207 (52.7)		1.00
Past	159 (38.1)	148 (37.7)		0.97 (0.72–1.30)
Current	27 (6.5)	38 (9.7)		0.58 (0.34–0.98)