Table 3.
Sources of sugar and endometrial cancer risk in The EDGE Study.
| Sources of Sugar | Cases (n=417) | Controls (n=395) | OR1 | 95% CI | OR2 | 95% CI |
|---|---|---|---|---|---|---|
| Total Sugary Foods & Drinks (servings/1000 kcal) | ||||||
| (<3.90) | 73 (17.5) | 99 (25.1) | 1.00 | 1.00 | ||
| (3.90–4.74) | 96 (23.0) | 99 (25.1) | 1.32 | (0.87–2.00) | 1.38 | (0.86–2.19) |
| (4.75–5.76) | 135 (32.4) | 98 (24.8) | 1.88 | (1.26–2.82) | 1.46 | (0.93–2.29) |
| (>5.76) | 113 (27.1) | 99 (25.1) | 1.66 | (1.10–2.51) | 1.38 | (0.87–2.20) |
| p trend | <0.01 | 0.22 | ||||
| Dessert Foods (servings/1000 kcal) | ||||||
| (<0.25) | 94 (22.5) | 100 (25.3) | 1.00 | 1.00 | ||
| (0.25–0.52) | 77 (18.5) | 97 (24.6) | 0.85 | (0.56–1.29) | 0.77 | (0.49–1.23) |
| (0.53–1.08) | 112 (26.9) | 100 (25.3) | 1.19 | (0.80–1.76) | 1.10 | (0.70–1.72) |
| (>1.08) | 134 (32.1) | 98 (24.8) | 1.48 | (0.99–2.20) | 1.29 | (0.83–2.01) |
| p trend | 0.01 | 0.07 | ||||
| Non-Dessert Foods (servings/1000 kcal) | ||||||
| (<2.92) | 80 (19.2) | 99 (25.1) | 1.00 | 1.00 | ||
| (2.92–3.69) | 122 (29.3) | 98 (24.8) | 1.61 | (1.08–2.41) | 1.45 | (0.93–2.27) |
| (3.70–4.46) | 102 (24.5) | 99 (25.1) | 1.31 | (0.87–1.97) | 1.21 | (0.77–1.91) |
| (>4.46) | 113 (27.1) | 99 (25.1) | 1.52 | (1.01–2.29) | 1.17 | (0.74–1.84) |
| p trend | 0.37 | 0.80 | ||||
| Sugary Drinks (servings/1000 kcal) | ||||||
| (<0.02) | 88 (21.1) | 98 (24.8) | 1.00 | 1.00 | ||
| (0.02–0.09) | 109 (26.1) | 99 (25.1) | 1.22 | (0.82–1.83) | 1.29 | (0.83–2.00) |
| (0.10–0.33) | 94 (22.5) | 100 (25.3) | 1.01 | (0.67–1.52) | 1.07 | (0.67–1.69) |
| (>0.33) | 126 (30.2) | 98 (24.8) | 1.42 | (0.96–2.11) | 1.48 | (0.94–2.33) |
| p trend | 0.11 | 0.14 | ||||
| Total Sugars (g/1000 kcal) | ||||||
| (<46.54) | 95 (22.8) | 98 (24.8) | 1.00 | 1.00 | ||
| (46.54–60.68) | 99 (23.7) | 100 (25.3) | 1.05 | (0.70–1.56) | 1.25 | (0.80–1.97) |
| (60.69–78.55) | 108 (25.9) | 99 (25.1) | 1.21 | (0.82–1.81) | 1.28 | (0.82–1.99) |
| (>78.55) | 115 (27.6) | 98 (24.8) | 1.36 | (0.91–2.04) | 1.43 | (0.91–2.27) |
| p trend | 0.09 | 0.15 | ||||
| Added Sugars (g/1000 kcal) | ||||||
| (<16.27) | 73 (17.5) | 99 (25.1) | 1.00 | 1.00 | ||
| (16.27–24.06) | 108 (25.9) | 98 (24.8) | 1.61 | (1.06–2.44) | 1.47 | (0.92–2.33) |
| (24.07–34.16) | 99 (23.7) | 100 (25.3) | 1.35 | (0.89–2.05) | 1.27 | (0.80–2.02) |
| (>34.16) | 137 (32.9) | 98 (24.8) | 1.94 | (1.29–2.92) | 1.84 | (1.16–2.92) |
| p trend | <0.01 | 0.02 | ||||
| % Kcal from sweets | ||||||
| (<6.50) | 79 (18.9) | 95 (24.1) | 1.00 | 1.00 | ||
| (6.50–11.50) | 91 (21.8) | 100 (25.3) | 1.09 | (0.72–1.65) | 1.16 | (0.73–1.85) |
| (11.51–17.90) | 109 (26.1) | 100 (25.3) | 1.27 | (0.84–1.92) | 1.22 | (0.78–1.92) |
| (>17.90) | 138 (33.1) | 100 (25.3) | 1.62 | (1.08–2.43) | 1.49 | (0.94–2.35) |
| p trend | 0.01 | 0.08 |
OR: Odds Ratio, CI: Confidence Interval
OR1: adjusted for age (continuous), energy intake (continuous)
OR2: additionally adjusted for education (high school or less, college, graduate school), race (White, Black, Other, Hispanic), age at menarche (continuous), menopausal status (premenopausal, postmenopausal) and age at menopause for postmenopausal women (<40, 42–54, ≥ 55, unknown), parity (0–1, 2, 3–4), oral contraceptive use (ever, never), HRT use (never, unopposed estrogen only, any combined HRT), BMI (continuous), smoking status (never, past, current) and pack-years for ever smokers (continuous), physical activity (METs for reported average hours per week of moderate or strenuous recreational activities). Further adjustment for diabetes (no, yes), fiber intake (g), or date of interview did not essentially change risk estimates.