Table 1.
Cytokine gene expression in ATI-like cells infected by IAV and MHV-1.a
| Gene | Fold change vs. mockb |
|
|---|---|---|
| IAV | MHV-1 | |
| Bcl6 | 2.8 | 4.0 |
| Ccl2 | 2.2 | 3.2 |
| Ccl20 | 3.1 | 11.1 |
| Ccl4 | 2.1 | 2.0 |
| Ccl7 | 2.2 | 3.0 |
| Ccl8 | 2.6 | 2.3 |
| Ccr3 | 3.2 | 3.8 |
| Cxcl1 | 5.0 | 11.5 |
| Cxcl10 | 8.0 | 5.2 |
| Cxcl13 | 5.6 | 2.1 |
| Il10 | 2.4 | 10.7 |
| Il16 | 2.8 | 5.8 |
| Il1b | 2.1 | 10.3 |
| Il1f6 | 3.0 | 3.7 |
| Lta | 2.6 | 5.6 |
| Ltb | 2.3 | 25.2 |
| Tnf | 9.1 | 6.0 |
| Tnfrsf1b | 2.7 | 5.2 |
a
RNA was extracted from IAV or MHV-1 infected ATI-like cells 24 h p.i. and mRNA for inflammatory cytokines and receptors was quantified by qPCR Array (SABiosciences). Genes included are those with at least a two fold increase compared to mock-inoculated cells in at least two replicate experiments.
b
Fold change values are representative values from three (IAV) or two (MHV-1) replicate samples.