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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Methods. 2013 May 11;61(1):3–9. doi: 10.1016/j.ymeth.2013.04.024

Figure 2.

Figure 2

Daigrammatic representation of IL-1β processing. IL-1β is expressed as an inactive precursor protein that must be cleaved to an active form by caspase 1 in secretory lysosomes. Since it has no signal sequence, it is not actively secreted, and its exit from the cell is not completely known, although exocytosis and cell death is known to release the mature active protein. Reprinted with permission from Institute Pasteur. http://www.pasteur.fr/ip/easysite/pasteur/en/research/scientific-departments/infection-and-epidemiology/units-and-groups/cytokines-e-inflammation/figures