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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: J Control Release. 2013 Apr 6;169(0):17–27. doi: 10.1016/j.jconrel.2013.03.033

Fig. 5. The TC-1-GR tumor cells that overexpress RRM1 are also resistant to Ara-C, and 4-(N)-Ara-CC18-SLNs overcome the resistance.

Fig. 5

(A) The cytotoxicity of Ara-C in TC-1 and TC-1-GR cells in culture (n = 8). aP < 0.001. (B) The cytotoxicity of Ara-C in TC-1-GR cells that were transfected with RRM1-specific siRNA or control siRNA (n = 7–10). bP < 0.05, cP < 0.001. (C) The IC50 values of Ara-C and 4-(N)-Ara-C-C18-SLNs in TC-1-GR cells (n = 4). dP < 0.01. In A–C, cells were incubated with Ara-C or 4-(N)-Ara-C-C18-SLNs for 48 h.

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