Fig. 6. A cartoon depicting how the uptake of gemcitabine, 4-(N)-GemC18 in solution, or 4-(N)-GemC18-SLNs influence their intracellular metabolism and activity against tumor cells.
CDA, (deoxy)cytidine deaminase; dCK, deoxycytidine kinase; dFdC, gemcitabine; dFdCMP, gemcitabine monophosphate; dFdCDP, gemcitabine diphosphate; dFdCTP, gemcitabine trisphosphate; dNDP, deoxyribonucleoside diphosphate; dNTP, deoxyribonucleotide triphosphate; hENT, human equilibrative nucleoside transporter; NDP, ribonucleoside diphosphates; RR, ribonucleotide reductase