Table 2.
Functional sensitivity and limit of detection of other biomarkers with the cardiac biochip array (multiplex) as provided by the manufacturer.The respective cut off values and release kinetics are also indicated
| Calibrators | LLOD (ng/ml) | ULOD (ng/ml) | Cut off value Normal (ng/l) | Cut off valueMI (ng/ml) | Onset (hrs) | Peak (hrs) | Duration (hrs) | Reference |
|---|---|---|---|---|---|---|---|---|
| GP-BB | 1.97 | 200 | 2-4 | 8-12 | 24-36 | [40,41] | ||
| CAIII | 0.2 | 200 | Skeletal Muscle Only | |||||
| MYO | 1.8 | 700 | 6-85 | 450 | 1-4 | 6-7 | 18-24 | [42,43] |
| CK-MB | 0.4 | 100 | 3-4 | 12 | 3-12 | 14-16 | 24-36 | [43-45] |
| H-FABP | 0.15 | 100 | 0 | 5 | 1-3 | 6 | 18-30 | [43,45,46] |
| cTnI | 0.18 | 50 | 0 | 5 | 3-12 | 18-24 | 216 | [43,47] |
Carbonic anhydrase III (CAIII) is expressed exclusively in skeletal muscle and restricted to skeletal muscle injury in association with MI [48].