Table 2.
Hematological measurements, homocysteine, vitamin B-6 status, indicators of oxidative stress, and antioxidant capacities in critically ill patients on the 1st and 7th days of admission to the surgical intensive care unit1.
| Variables | Day 1 | Day 7 | Δ (Day 7 − Day 1)2 |
|---|---|---|---|
| (n = 37) | (n = 37) | (n = 37) | |
| Albumin (g/L) | 2.81 ± 0.14 | 2.76 ± 0.07 | −0.05 ± 0.14 |
| Hemoglobin (g/dL) | 10.31 ± 0.36a | 9.32 ± 0.32b | −0.99 ± 0.31 |
| Creatinine (mg/dL) | 1.90 ± 0.33 | 2.07 ± 0.39 | 0.11 ± 0.20 |
| C-reactive protein (mg/dL) | 10.54 ± 1.28 | 9.19 ± 1.15 | −1.54 ± 1.43 |
| Vitamin B-6 status | |||
| Plasma PLP (nmol/L) | 30.64 ± 4.73 | 37.11 ± 4.92 | 6.47 ± 10.99 |
| <20 nmol/L (n, %) | 16 (43.24%) | 12 (32.43%) | |
| Erythrocyte PLP (pmol/g Hb) | 444.99 ± 104.88a | 669.55 ± 156.62b | 224.56 ± 92.76 |
| Plasma PLP/Erythrocyte PLP ratio | 0.11 ± 0.02 | 0.10 ± 0.01 | −0.00 ± 3.37 |
| Oxidative stress | |||
| Plasma homocysteine (μmol/L) | 18.38 ± 2.73a | 19.99 ± 2.70b | 1.61 ± 3.37 |
| >15 μmol/L (n, %) | 15 (40.54%)a | 22 (59.46%)b | |
| MDA (μmol/L) | 1.00 ± 0.08 | 1.02 ± 0.09 | 0.02 ± 0.06 |
| Antioxidant capacity | |||
| Total antioxidant capacity (μmol/L) | 4042.28 ± 82.65a | 4243.33 ± 84.62b | 201.05 ± 66.63 |
| SOD (U/mL) | 10.60 ± 1.21 | 11.01 ± 1.31 | 0.41 ± 1.70 |
| GST (nmol/min/mL) | 4.37 ± 0.62a | 8.99 ± 0.56b | 1.75 ± 4.29 |
| GPx (nmol/min/mL) | 100.33 ± 5.52 | 98.92 ± 5.73 | −1.41 ± 5.64 |
1Values are means ± standard error of mean. PLP: pyridoxal-5′-phosphate; Hb: hemoglobin; MDA: malondialdehyde; SOD: superoxide dismutase; GST: glutathione S-transferase; GPx: glutathione peroxidase.
2Δ (Day 7 − Day 1) is the value of the difference between day 7 and day 1.
a,bValues are significantly different between day 1 and day 7; P < 0.05.