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Cumulative biliary excretion of curcumin and its metabolites after i.v. administration of (A) nanocurcumin (equivalent to 10 mg/kg curcumin) and (B) solvent solubilized curcumin (10 mg/kg) to SD rats. Data are mean ± S.D., n = 5 rats. Bile samples were collected at 1 h intervals for the first 8 h. The %ID of curcumin and metabolites in bile was calculated as: (curcumin or metabolite molar concentration × volume of collected bile)/total molar dose × 100%.
