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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Cancer Ther. 2013 Mar 28;12(6):901–912. doi: 10.1158/1535-7163.MCT-12-1003

Figure 6. XL888 inhibits growth of NRAS mutant melanoma cells in 3D cell culture and a mouse xenograft model.

Figure 6

A: XL888 (XL: 300nM, 5 days) induces cell death 3D spheroids compared to control (CT). Green: live cells and Red: dead cells. B: XL888 inhibits the growth of M245 melanoma xenografts. Animals bearing M245 xenografts were treated with XL888 thrice per week (125 mg/kg). Data shows growth curves normalized to starting volumes, bar graph shows mean tumor volumes after 18 days of XL888 treatment. XL888 treatment led to significant levels of growth inhibition (P=0.017). C: Heatmap showing the increase in HSP70 isoform 1 (HSP71) expression in XL888 treated (15 days, 125 mg/kg) xenograft samples compared to vehicle controls. D: XL888 treatment (10 days) led to the induction of apoptosis in established M245 xenografts as measured by increased TUNEL staining (green).