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. Author manuscript; available in PMC: 2013 Jun 16.
Published in final edited form as: Expert Opin Emerg Drugs. 2011 May 4;16(3):479–491. doi: 10.1517/14728214.2011.576670

Figure 1. Mechanism of nerve growth factor induced hyperalgesia.

Figure 1

NGF binds its high affinity receptor TrkA causing phosphorylation and increased activity of TRPv1. NGF undergoes retrograde transport to the dorsal root ganglion, increasing expression of pain signaling factors including substance P, calcitonin gene related peptide(CGRP), TRPV1, brain-derived neurotrophic factor (BDNF) etc., some of which provide central pain perception via release into spinal cord synapses. Increased peripheral hypersensitivity can also be exacerbated by anteriograde transport of TRPV1.