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. Author manuscript; available in PMC: 2013 Jun 16.
Published in final edited form as: Cell Metab. 2010 Dec 1;12(6):593–605. doi: 10.1016/j.cmet.2010.11.011

Figure 5. Caspase-1 Blockage Improves Insulin Sensitivity.

Figure 5

(A) Insulin tolerance test in male ob/ob animals (2 months of age at start of intervention) orally treated with a chemical caspase-1 inhibitor (Pralnacasan) or vehicle for 2 weeks (n = 5 per group).

(B) IL-1β concentrations (pg/ml) measured in total white adipose tissue of ob/ob mice receiving vehicle or a caspase-1 inhibitor (n = 5 per group).

(C) Bodyweight change (in %) during oral treatment of ob/ob animals with vehicle or a caspase-1 inhibitor (n = 5 per group).

(D) Food intake (kcal/day) of ob/ob animals orally treated with a chemical caspase-1 inhibitor or vehicle for 2 weeks.

(E) Percentage of epididymal white adipose tissue.

(F) Lipid composition of white adipose tissue.

(G) Desaturation indexes in vehicle or caspase-1 inhibitor-treated animals.

(H) Bodyweight development of WT or caspase-1−/− animals (2 months of age at start of intervention) fed a LFD or HFD for 10 weeks (n = 10 per group).

(I) Food intake (kcal/day) of WT or caspase-1−/− fed a LFD or HFD.

(J) Insulin tolerance test in WT and caspase-1−/− animals fed a HFD for 10 weeks (n = 5 per group). Data are presented as mean ± SEM. Asterisks depict statistically significant differences between control and experimental groups.*p < 0.05, **p < 0.005.