Table 1. Body weight and biochemical parameters in ApoE−/− mice at baseline (8th week of age) and at the end (just before euthanasia). We comparatively evaluated the baseline, the final period and the amount of changes in body weight and biochemical parameters among groups. Results are expressed as mean±standard deviation.
| Groups | Time | CO (N=15) | SED (N=15) | EX (N=15) | P | P1 | P2 | P3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Body weight (g) | Baseline | 22.3±2.6 | 21.5±3.1 | 21.9±1.2 | 0.726 | 0.820 | 0.717 | 0.810 | ||||||||
| End | 35.3±8.1 | 36.2±3.9 | 33±3.5 | 0.224 | 0.692 | 0.332 | 0.166 | |||||||||
| FPG (mg/dL) | ||||||||||||||||
| Baseline | 123.2±39.3 | 122.8±65 | 133.8±24.2 | 0.271 | 0.910 | 0.506 | 0.867 | |||||||||
| End | 350±45.5 | 354.1±49.9 | 296±25.4*# | 0.147 | 0.961 | 0.145 | 0.137 | |||||||||
| MMP-2 (ng/mL) | ||||||||||||||||
| Baseline | 91.3±46.8 | 92.4±29.1 | 95.3±21.3 | 0.554 | 0.891 | 0.447 | 0.781 | |||||||||
| End | 146.31±48.1 | 158.65±23.1 | 119.33±33.5*# | 0.003 | 0.874 | 0.009 | <0.001 | |||||||||
| MMP-3 (ng/mL) | ||||||||||||||||
| Baseline | 25.3±12 | 22±17.3 | 22.2±10.9 | 0.870 | 0.646 | 0.941 | 0.951 | |||||||||
| End | 70.89±38 | 99.084±42.1 | 53.99±34.6*# | 0.029 | 0.302 | 0.122 | 0.013 | |||||||||
| IL-6 (pg/mL) | ||||||||||||||||
| Baseline | 21.2±6.4 | 19.42±4.2 | 23.79±3.1 | 0.833 | 0.893 | 0.888 | 0.791 | |||||||||
| End | 89±34.8 | 94.63±24.5 | 61.2±20.8*# | 0.031 | 0.766 | 0.041 | 0.025 | |||||||||
| TC (mg/dL) | ||||||||||||||||
| Baseline | 221.5±51.3 | 208±43.3 | 236.4±40.8 | 0.698 | 0.881 | 0.812 | 0.558 | |||||||||
| End | 679.5±212 | 638±203.2 | 556±110.7 | 0.593 | 0.857 | 0.608 | 0.901 | |||||||||
| TG (mg/dL) | ||||||||||||||||
| Baseline | 59.5±22.1 | 68.2±19 | 75.8±23.5 | 0.662 | 0.791 | 0.602 | 0.825 | |||||||||
| End | 66±32.1 | 70.1±41.1 | 89.2±35.5 | 0.478 | 0.860 | 0.447 | 0.871 | |||||||||
CO, control; SED, sedentary; EX, exercise. P, one-way ANOVA; P1, CO vs SED; P2, CO vs EX; P3, SED vs EX using post-hoc Tuckey test at baseline and at the end; FPG, fasting plasma glucose; MMP-2, matrix metalloproteinase-2; MMP-3, matrix metalloproteinase-3; IL-6, interleukin-6; TC, total cholesterol; TG, triglycerides. Comparison of the amount of changes of variables among groups using one-way ANOVA test for repeated measures and post-hoc Tuckey test:
*
P<0.05, EX vs CO group;
#
P<0.05, EX vs SED group.