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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Nature. 2012 Aug 2;488(7409):49–56. doi: 10.1038/nature11327

Figure 4. Tandem duplication of SNCAIP defines a novel subtype of Group 4.

Figure 4

a, Highly recurrent, focal, single copy gain of SNCAIP in Group 4. b, Paired-end mapping verifies recurrent tandem duplication of SNCAIP in Group 4. c, Schematic representation of SNCAIP tandem duplication. d, SNCAIP is a Group 4 signature gene. Upper panel. SNCAIP expression across subgroups in a published series of 103 primary medulloblastomas. Lower panel. SNCAIP ranks among the top 1% (rank=39/16,758) of highly expressed genes in Group 4. e, NMF consensus clustering of 188 expression-profiled Group 4s supports two transcriptionally distinct subtypes designated 4α and 4β (Cophenetic coefficient=0.9956). 21/22 SNCAIP duplicated cases belong to Group 4α (P=3.12E-08, Fisher’s exact test). f, SNCAIP expression is significantly elevated in Group 4α vs. 4β (P=9.31E-14, Mann-Whitney test). g, Group 4α cases harboring SNCAIP duplication exhibit a ~1.5-fold increase in SNCAIP expression.