TABLE 2.
Signals regulating axonal mRNA translation
| Signals | References | |||
|---|---|---|---|---|
| Netrin-1 | induces PS | of | β-actin, par3 | 24, 25 |
| via | PI3K, Erk1/2, p38, mTOR | 64 | ||
| requires PS | for | GC turning and collapse; axon outgrowth | 64, 67 | |
| Sema3A | induces PS | of | RhoA | 26 |
| requires PS | for | GC collapse | 26, 64 | |
| Slit2 | induces PS | of | Cofilin | 27 |
| via | MAPK | |||
| requires PS | for | GC collapse | ||
| LPA | does not induce PS | 64 | ||
| S1P | does not induce PS | 66 | ||
| EphrinB/EphB | does not induce PS | 65 | ||
| PACAP | requires PS | for | GC turning | 63 |
| via | PKA, Rho GTPases | |||
| EphA | inhibits PS | via | Tsc2 | 71 |
| En2 | induces PS | of | components of EphrinA5 signaling | 72 |
| requires PS | for | GC turning | 73 | |
| NGF | induces PS | of | CREB | 19 |
| requires PS | for | survival of DRG neurons | ||
| induces PS | of | par3 | 67 | |
| requires PS | for | induced axon outgrowth | ||
| does not induce PS | of | β-actin | 23 | |
| BDNF | induces PS | of | β-actin | 25 |
| via | ZBP | |||
| requires PS | for | GC turning | ||
| NT3 | induces PS | of | β-actin | 23 |
| via | PKA |
LPA, lysophosphatidic acid; PACAP, pituitary adenylate cyclase-activating polypeptide; NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; mTOR, mammalian target of rapamycin; CREB, CRE-binding protein; ZBP, zipcode binding protein; S1P, sphingosine-1-phosphate;MAPK, mitogen-activated protein kinase; PKA, protein kinase A.