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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Neurobiol Dis. 2008 Mar 10;30(3):312–322. doi: 10.1016/j.nbd.2008.01.015

Figure 1.

Figure 1

Sertraline increases survival and improves motor behavioral performance, but does not affect body weight loss in HD mice. Twelve-week-old male HD mice were administered sertraline daily at doses of 5, 10, and 20 mg/kg or vehicle (0.2% tween -80) until the end of study. (a) Survival of HD mice was significantly extended by sertraline treatment in a dose-dependent manner. The p values are 0.041 between vehicle and sertraline 5 mg/kg groups, 0.039 between vehicle and sertraline 10 mg/kg groups, and 0.012 between vehicle and sertraline 20 mg/kg groups by Kaplan-Meier analysis. (b) There was no significant difference in body weight loss by sertraline treatment. (c and d) Motor behavioral performance was evaluated by an accelerating rotarod apparatus in 16-(c) and 18-(d) week-old mice, n=8–15. The values are the mean and SE. *p<0.05, compared to the value of nontransgenic-control group; **p<0.05 compared to the values of HD-vehicle group by Standard student t-tests.