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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Neurobiol Dis. 2008 Mar 10;30(3):312–322. doi: 10.1016/j.nbd.2008.01.015

Figure 2.

Figure 2

Sertraline reduces brain atrophy but not huntingtin inclusions in N171-82Q HD mice. (a) Representative photomicrographs of brain sections of HD mice and nontransgenic mice (nontg), scale bar=120 μm. (b) Quantification of striatal volume and (c) cerebral lateral ventricle volume. Data are presented as mean and SE, n= 4 mice in each group. *p<0.05, compared to the value of nontg control group; **p<0.05 compared to the value of HD-vehicle group by Standard Student t-tests. (d) Representative micrographs of htt inclusions immunostained by EM48 antibody in HD mice treated with sertraline or vehicle. Scale bar =20 μm.