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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Neurobiol Dis. 2008 Mar 10;30(3):312–322. doi: 10.1016/j.nbd.2008.01.015

Figure 6.

Figure 6

Neurogenesis induced by sertraline is required for its survival extension effect and improvement of motor performance in HD mice. (a) Radiographic alignment of the mouse brain with 8 ×10 mm radiation treatment port (left) and corresponding structures (right). The stereotactic head holder is visible in the radiograph as bars on either side of the head. Structures in the right panel are the right and left lateral ventricles (green, red) and dentate gyrus of hippocampus (purple, blue) from the atlas of Paxions and Franklin (2001). (b) There was significant reduction of cell proliferation in both SVZ and SGZ by X-ray irradiation, which was not rescued by sertraline treatment. The values are mean and SE from four HD mice in each group. *p<0.05 compared to the values of sham-vehicle group by standard student t-tests. (c) X-ray irradiation abolished the improved motor performance by sertraline in HD mice. Data are presented as mean and SE from 10 mice in each group. *p<0.05 compared to the values of HD-sham group, #p<0.05 compared to the values of HD-sham-sertraline group by standard student t-tests. (d) The survival extension effect of sertraline was partially eliminated by X-ray irradiation. Survival was analyzed by Kaplan-Meier analysis. The p value between sham group and sham+ser group is 0.00125; the p value between X-ray+ser group and sham+ser group is 0.0248.