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. 2013 Jun 17;3:1995. doi: 10.1038/srep01995

Figure 7. Automated single hBK channel inhibition by Aβ1-42 from both the intra- and extracellular sides.

Figure 7

(a) Effect of Aβ1-42 on single hBK channels before and after the addition of Aβ1-42 to the extracellular side. (b) Effect of Aβ1-42 application on the lipid bilayer (EggPC) itself. (c, d) The intra- (c) and extracellular side (d) effects of the application of Aβ1-42 to the hBK channel. (e, f) Point current histograms for the hBK channel obtained before (top) and after (bottom) the application of Aβ1-42 from the intracellular (e) or extracellular side (f) direction. (g, h) Effects of Aβ1-42 on the channel conductance (g) and open probability (h) (n = 12, mean ± S.D.). The significance was assessed by t-tests: *P < 0.05, **P < 0.01.