Fig. 2.

Validation of sepsis-induced hypotension and organ damage in WT mice after CLP. (A and B) Comparison of in vivo telemetric blood pressure and locomotor activity monitoring in WT mice before and during 24 h of CLP-induced sepsis versus sham-operated WT mice. (C) Plasma level of LDH as an indirect measure of multiple organ injury in WT mice in 6 and 24 h after CLP-induced sepsis or sham operation. (D) Comparison of BUN level in WT mice after 24 h CLP-induced sepsis or sham-operated WT mice. *P < 0.05, **P < 0.01 comparing WT CLP with WT sham-operated mice by t test. Data are mean ± SEM.