Fig. 1.

ZNF408 chromosomal location, genomic structure, and ZNF408 protein characteristics. (A) Part of chromosome 11 showing the W05-215 linkage interval. The locations of the FEVR genes FZD4 and LRP5, as well as the boundaries of the EVR3 locus (16), are depicted. (B) Exon-intron structure of the ZNF408 gene. (C) Schematic overview of ZNF408, a protein of 720 amino acids that is predicted to contain one putative SET and 10 C2H2-type zinc-finger domains. The position of the histidine residue that is mutated to a tyrosine is indicated. (D) Sequence comparison of ZNF408 proteins from several vertebrate species. The alignment contains the histidine residue that is mutated (in bold type), along with 10 flanking amino acids on each side. Identical residues are black on a white background, whereas nonidentical residues are black on a gray background.