Targeting SOBIR1 and SOBIR1-like suppresses Cf-4–mediated resistance of tomato. Cf-4 tomato was inoculated with the indicated TRV constructs, and 3 wk later plants were inoculated with an Avr4-secreting, GUS-transgenic strain of C. fulvum. A non TRV-inoculated susceptible MM-Cf-0 plant was included as control. Two weeks later, leaflets were stained for GUS activity to detect C. fulvum colonization. For the Cf-4 tomato plants, the amount of successful colonization attempts (blue spots) vs. the total amount of leaflets analyzed for that particular experiment is indicated between parentheses. The experiment was performed three times, and representative pictures are shown.