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Mutations G347U and G299A similarly alter the conformation of h14 and its interaction with h8. (A) The structural integrity of h14 is normally maintained by the base triple G347⋅A160⋅C342, as shown in the wild-type 70S structure (gray; PDB ID code 2WDG). In the presence of either G347U (B, green) or G299A mutations (C, blue), h14 widens, resulting in disruption of this base triple and the interaction network of B8.
