Fig. 6.

The HMGA2/TET1/HOXA pathway regulates breast tumorigenesis. (A) Comparison of the genes regulated by HMGA2, TET1, or HOXA9 in 1833 cells (human breast cancer cells; hBrCa). (B) Scheme illustrating HMGA2/TET1/HOXA signaling pathway in breast tumorigenesis. (C) Kaplan–Meier analysis of gene expression data from 101 breast tumor patients (see Table S3 for patient information). Patients were stratified for survival using HMGA2, TET1, HOXA9, HOXA7, or the complete pathway as indicated. (Right) Red line, high HMGA2 and low TET1/HOXAs (n = 34); blue line, low HMGA2 and high TET1/HOXAs (n = 35); P, χ² P value.