Fig. 5.

Crystal structures of V122I-TTR ligand complexes. (A) Quaternary structure of AG10 bound to V122I-TTR shown as a ribbon representation with monomers colored individually and positions of each of the V122I mutations shown as black spheres located on the H β-strand, which interacts with the adjacent AB-loop on the AC/BD interface. (B) AG10 in complex with V122I-TTR. (C) Tafamidis in complex with V122I-TTR. Close-up views of one of the two identical T₄ binding sites with different colored ribbons for the two monomers of the tetramer composing the binding site. A Connolly molecular surface (40) was applied to residues within 10 Å of ligand in the T₄ binding pocket and colored gray for hydrophobic and purple for polar residues.