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Knockdown of CCT subunits in J774A.1 cells confers resistance to LT. CCT knockdown in J774A.1 cells was allowed to proceed for 5 d. (A and B) Cell survival after challenge with PA (11 nM) and LF for 6 h at 37 °C. B shows cell survival at 0.25 nM LF. NT, nontargeting shRNA. Data are expressed as mean ± SD of three technical replicates. ***P < 0.001 (C) Western blot to indicate the extent of CCT knockdown. cRel was used as a loading control.
