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. 2013 May 28;110(24):9914–9919. doi: 10.1073/pnas.1304046110

Fig. 3.

Fig. 3.

IL-4/IL-13 signaling promotes cell cycle progression after liver injury. (A) Global gene expression analysis of WT and IL-4/IL-13−/− livers was performed 2 d after injury with CCl4. Gene ontology (GO) terms associated with cell cycle and mitosis are enriched among the differentially expressed genes. (B) Heat map presentation of differentially expressed genes in livers of WT and IL-4/IL-13−/− mice 2 d after injury with CCl4 (red, high; green, low). (C) Quantitative RT-PCR analysis of genes associated with hepatocyte proliferation and liver regeneration. mRNAs from WT and IL-4/IL-13−/− mice were analyzed 2 d after injury with CCl4 (n = 3–5 per genotype and treatment). (D) Western blot analysis of FoxM1 in WT and IL-4/IL-13−/− livers. (E) Quantitative RT-PCR analysis of genes associated with hepatocyte proliferation in WT and ΔdblGATA mice was performed 2 d after PH (n = 5–8 per genotype and treatment). *P < 0.05, **P < 0.01, ***P < 0.001. All data are presented as mean ± SEM.