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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Mol Biochem Parasitol. 2007 May 13;155(1):18–25. doi: 10.1016/j.molbiopara.2007.05.003

Figure 2. Frequency of resistance to 5-FOA in wild type and MSH2-2 disrupted parasites.

Figure 2

Swiss mice were intraperitoneally injected with P. berghei infected red blood cells, and treated as indicated once or twice a day (T) with 10 mg/kg 5-FOA. Parasitemia was measured daily by thin blood smear. (A and B) Wild type parasites appear to have a higher frequency of drug resistance than PbMSH2-2 disrupted parasites. (C) PbMSH2-2 disrupted parasites which have been passaged through the sexual lifecycle stages appear to have a higher frequency of drug resistance than sexually passaged wild type parasites. (D) Sexually passaged PbMSH2-2 disrupted parasites show a higher frequency of drug resistance than asexually passaged mutant parasites.