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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Cancer Epidemiol. 2013 Mar 26;37(4):424–427. doi: 10.1016/j.canep.2013.03.003

Table 2.

Clinical characteristics of 21individuals carrying germline HOXB13G84E mutation

No. Studya Subjects Gender Ageb at diagnosis, y Family historyc
1 OFCCR Case M 73 None
2 OFCCR Case M 63 None
3 OFCCR Case F 66 None
4 OFCCR Case M 51 Father, 5 Paternal Uncles
(PrCa, 74, 60, 63, 72, 74, 74)),
Maternal Grandfather (CRC,
81)
5 OFCCR Case F 59 Paternal Uncle, Maternal
Grandfather (PrCa, 78, 80)
6 OFCCR Case M 45 2 Maternal Uncles (CRC, 69,
75), 2 Paternal Uncles
(PrCa,UK, UK)
7 OFCCR Case F 59 None
8 OFCCR Case M 42 Paternal Uncle (CRC, 60)
9 OFCCR Case F 69 Maternal Uncle, Maternal
Grandfather (CRC, UK, UK)
10 OFCCR Case M 39 None
11d OFCCR Case M 40 Father, Mother, Sister,
Maternal Uncle (CRC, 58, 54,
56, 54)
12e ACCFR Case M 22 None
13 ACCFR Case F 42 Father, Brother (PrCa, 64, 49)
14 ACCFR Control M 52 Father, Paternal Uncle,
Maternal Uncle (CRC, 44, UK,
UK)
15 OFCCR Control M 59 Father (PrCa)
16 OFCCR Control F 73 None
17 OFCCR Control M 68 None
18 OFCCR Control F 54 Father, Mother, Maternal
Grandfather (CRC), Maternal
Uncle (PrCa)
19 HW Control F 57 Brother (CRC, 54)
20 PC Control M 59 Father, Uncle (PrCa, 79, 85)
21 PC Control M 66 None
a

Ontario Colon Cancer Family Registry (OFCCR), Australasian Colorectal Cancer Family Registry (ACCFR), Health Watch Study (HW), Prostate Cancer Study (PC)

b

Age for cases is their age of diagnosis and for controls is their age of consent

c

Family history of colorectal cancer (CRC) and prostate cancer (PrCa) among the first and second degree relatives of the probands. The age at diagnosis was provided for whom it was available.UK= age of diagnosis is unkown

d

This individual carried a MLH1 mutation (c.1217_23dupGTCAGCC, p.Q409fsX85)

e

This individual carried a MSH6 mutation (c.3311_3312delTT, p.Phe1104TrpfsX3)