Table 2.

Clinical characteristics of 21individuals carrying germline HOXB13G84E mutation

No.	Studya	Subjects	Gender	Ageb at diagnosis, y	Family historyc
1	OFCCR	Case	M	73	None
2	OFCCR	Case	M	63	None
3	OFCCR	Case	F	66	None
4	OFCCR	Case	M	51	Father, 5 Paternal Uncles (PrCa, 74, 60, 63, 72, 74, 74)), Maternal Grandfather (CRC, 81)
5	OFCCR	Case	F	59	Paternal Uncle, Maternal Grandfather (PrCa, 78, 80)
6	OFCCR	Case	M	45	2 Maternal Uncles (CRC, 69, 75), 2 Paternal Uncles (PrCa,UK, UK)
7	OFCCR	Case	F	59	None
8	OFCCR	Case	M	42	Paternal Uncle (CRC, 60)
9	OFCCR	Case	F	69	Maternal Uncle, Maternal Grandfather (CRC, UK, UK)
10	OFCCR	Case	M	39	None
11d	OFCCR	Case	M	40	Father, Mother, Sister, Maternal Uncle (CRC, 58, 54, 56, 54)
12e	ACCFR	Case	M	22	None
13	ACCFR	Case	F	42	Father, Brother (PrCa, 64, 49)
14	ACCFR	Control	M	52	Father, Paternal Uncle, Maternal Uncle (CRC, 44, UK, UK)
15	OFCCR	Control	M	59	Father (PrCa)
16	OFCCR	Control	F	73	None
17	OFCCR	Control	M	68	None
18	OFCCR	Control	F	54	Father, Mother, Maternal Grandfather (CRC), Maternal Uncle (PrCa)
19	HW	Control	F	57	Brother (CRC, 54)
20	PC	Control	M	59	Father, Uncle (PrCa, 79, 85)
21	PC	Control	M	66	None

^aOntario Colon Cancer Family Registry (OFCCR), Australasian Colorectal Cancer Family Registry (ACCFR), Health Watch Study (HW), Prostate Cancer Study (PC)

^bAge for cases is their age of diagnosis and for controls is their age of consent

^cFamily history of colorectal cancer (CRC) and prostate cancer (PrCa) among the first and second degree relatives of the probands. The age at diagnosis was provided for whom it was available.UK= age of diagnosis is unkown

^dThis individual carried a MLH1 mutation (c.1217_23dupGTCAGCC, p.Q409fsX85)

^eThis individual carried a MSH6 mutation (c.3311_3312delTT, p.Phe1104TrpfsX3)