Table 2.

Antioxidant parameters as well as AGE levels of rat liver homogenate. Group 1, control group; groups 2–4, rats treated with 50, 100, and 200 mg metanil yellow/kg body weight for 8 weeks, respectively; groups 5–7, rat groups treated with 50, 100, and 200 mg metanil yellow/kg body weight plus 2.5 g/kg bees' honey daily for 8 weeks, respectively.

	Group 1	Group 2	Group 3	Group 4	Group 5	Group 6	Group 7
MDA, nmol/mg protein	0.42 ± 0.06	1.49 ± 0.19a	5.1 ± 0.85a	9.37 ± 1.8a	0.85 ± 0.02b	1.45 ± 0.35a,c	1.9 ± 0.92a,d
GSH, nmol/mg protein	101 ± 5.8	72.5 ± 1.6a	45.9 ± 4.6a	26.7 ± 3.8a	79.5 ± 2.1	78.5 ± 2.1a,c	80.2 ± 1.3a,d
GST, nmol/mg protein	18.6 ± 1.5	11.1 ± 1.3a	6.29 ± 0.39a	4.2 ± 0.94a	14.76 ± 0.86b	10.54 ± 0.45a,c	10.3 ± 0.87a,d
SOD, U/mg protein	15.8 ± 1.1	10.5 ± 2.5a	9.6 ± 2.1a	3.1 ± 1.2a	14.25 ± 1.1b	11.2 ± 1.3a,c	10.97 ± 1.5a,d
CAT, U/mg protein	5.95 ± 0.5	3.12 ± 0.2a	2.41 ± 0.31a	1.1 ± 0.11a	4.56 ± 0.54b	4.29 ± 0.23c	3.1 ±0.67a,d
GSH-Px, U/mg protein	4.95 ± 0.21	3.1 ± 0.31a	2.05 ± 0.12a	1.15 ± 0.10a	4.67 ± 0.65b	4.12 ± 0.32c	3.87 ± 0.56d
AGE, ng/mg protein	20.6 ± 4.5	26.2 ± 5.5a	36.5 ± 5.5a	48.7 ± 8.5a	22.2 ± 5.5b	28.2 ± 5.5a,c	32.2 ± 5.5a,d

All values were expressed as mean ± S.D. of triplicate tests (n = 10).

^a P < 0.05 versus group 1, ^b P < 0.05 versus group 2, ^c P < 0.05 versus group 3, ^d P < 0.05 versus group 4.