Table 3.
Association between three ESR2 SNPs and ERβ Allred scores (n=135).
| SNP | Genotype | <6
|
6 to 7
|
8
|
p-valuea | ||||
|---|---|---|---|---|---|---|---|---|---|
| n | n | OR | 95% CI | n | OR | 95% CI | |||
| Part A. Tumors according to cytoplasmic ERβ Allred score
|
|||||||||
| rs8021944 | TT | 44 | 41 | Ref | 33 | Ref | |||
| TG+GG | 2 | 7 | 3.76 | 0.74–19.1 | 6 | 4.00 | 0.76–21.1 | 0.123 | |
| rs1256061 | CC | 15 | 13 | Ref | 5 | Ref | |||
| CA+AA | 28 | 30 | 1.24 | 0.50–3.05 | 30 | 3.21 | 1.03–10.0 | 0.056 | |
| rs10146204 | GG | 17 | 18 | Ref | 7 | Ref | |||
| GA+AA | 26 | 25 | 0.91 | 0.38–2.15 | 28 | 2.62 | 0.93–7.32 | 0.102 | |
| Part B. Tumors according to nuclear ERβ Allred score
|
|||||||||
| rs8021944 | TT | 17 | 33 | Ref | 68 | Ref | |||
| TG+GG | 1 | 1 | 0.52 | 0.03–8.76 | 13 | 3.25 | 0.40–26.6 | 0.048 | |
| rs1256061 | CC | 7 | 11 | Ref | 15 | Ref | |||
| CA+AA | 9 | 20 | 1.41 | 0.41–4.85 | 59 | 3.06 | 0.98–9.55 | 0.026 | |
| rs10146204 | GG | 9 | 13 | Ref | 20 | Ref | |||
| GA+AA | 7 | 18 | 1.78 | 0.53–6.02 | 54 | 3.47 | 1.14–10.6 | 0.017 | |
| Part C. Tumors according to total ERβ Allred score.
|
|||||||||
| rs8021944 | TT | 39 | 47 | Ref | 32 | Ref | |||
| TG+GG | 1 | 8 | 6.64 | 0.80–55.4 | 6 | 7.31 | 0.84–63.9 | 0.087 | |
| rs1256061 | CC | 14 | 14 | Ref | 5 | Ref | |||
| CA+AA | 23 | 35 | 1.52 | 0.61–3.78 | 30 | 3.65 | 1.15–11.6 | 0.029 | |
| rs10146204 | GG | 15 | 20 | Ref | 7 | Ref | |||
| GA+AA | 22 | 29 | 0.99 | 0.42–2.36 | 28 | 2.73 | 0.95–7.84 | 0.080 | |
Legend: SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval; Ref –reference category
a
Statistical significance of association between genotype and ERβ class (Wald chi-square test from ordered logistic regression).