FIG. 1.
(A) Schematic drawing of the MDS, showing the primary circuit (labeled 1) containing the whole blood of the patient. The blood cells are rejected by the plasma filter. In the second circuit (labeled 2), the plasma recirculates together with the S-layer fusion protein-coated microbeads, on which IgG shall be bound. After passing the plasma filter again, the purified plasma is combined with blood cells, and the whole blood is reinfused into the patient. (B) Scanning electron micrograph of the biocompatible, cellulose-based microbeads used for recrystallization of rSbpA31-1068/ZZ. (C) Schematic drawing showing the oriented recrystallization of the S-layer fusion protein rSbpA31-1068/ZZ on microbeads precoated with SCWP and binding of IgG to the ZZ-domains.