Figure 2. Genetic and Environmental Factors that Affect Acinar Cells or Ducts.

Premature trypsin activation may occur within the acinar cell or within the duct to initiate pancreatitis. The majority of known risk factors can be classified as primarily affecting the acinar cells or pancreatic ducts. Understanding the site of likely trypsin activation and mechanism may guide preventative strategies in the future. (from Solomon and Whitcomb⁷⁶).