Table 1.

Hepatic Malondialdehyde, Superoxide Dismutase, Catalase, and Glutathione Peroxidase Levels of Diabetic Rats After 42 Days of Streptozotocin Treatment

	Control			Berberine treated
	Intact	STZ	Amitriptyline	5 mg/kg	10 mg/kg	20 mg/kg
MDA (nM/g wet tissue)	23.06±3.88	37.31±3.13a	30.38±2.42ac	35.74±4.84a	29.35±3.56ad	24.19±5.38c
SOD (U/g protein)	232.63±35.37	389.13±57.22a	308.63±32.77ac	358.25±50.93a	304.75±27.76ad	284.13±42.82bc
CAT (κ/g protein)	1.50±0.32	2.93±0.33a	2.28±0.39ac	2.72±0.21a	2.29±0.33ad	1.92±0.14ac
GSH-Px (U/g protein)	0.23±0.08	1.76±0.17e	1.34±0.32eh	1.57±0.37e	1.32±0.28eg	1.01±0.53eg

Values are expressed as mean±SD of eight rats.

^aP<.01 and ^bP<.05 as compared with intact control by the LSD test.

^cP<.01 and ^dP<.05 as compared with STZ control by the LSD test.

^eP<.01 and ^fP<.05 as compared with intact control by the MW test.

^gP<.01 and ^hP<.05 as compared with STZ control by the MW test.

STZ, streptozotocin; MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase; GSH-Px, glutathione peroxidase; LSD, least-significant differences; MW, Mann–Whitney U.