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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Methods Mol Biol. 2012;929:583–600. doi: 10.1007/978-1-62703-050-2_21

Fig. 2.

Fig. 2

Simulated drug concentrations (left) and response curves (right) using a simple Emax model (Eq. 1). Drug concentrations follow monoexponential disposition: Cp = Coe(−kt). Co was set to 10, 100, or 1,000 units to achieve increasing dose levels. Parameter values were k = 0.12/h, Emax = 100 units, and EC50 = 15 units.