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. Author manuscript; available in PMC: 2013 Jun 17.
Published in final edited form as: Methods Mol Biol. 2012;929:583–600. doi: 10.1007/978-1-62703-050-2_21

Fig. 8.

Fig. 8

Structural model for irreversible effects (top panel) and signature profiles for irreversible effect model with a proliferating cell population (bottom panel). Response curves were simulated using Eq. 16 driven by drug concentrations following monoexponential disposition: Cp = Coe(−kt). Co was set to 0, 10, 100, or 1,000 units to achieve a control population and increasing dose levels. Pharmacokinetic parameter was k = 0.12/h. Pharmacodynamic parameters were k = 0.0005 units/h, ks = 0.03/h.