Table 1.
Normal | MCI | AD | p-valuec | |
---|---|---|---|---|
Sample size | ||||
N Baseline | 229 | 390 | 181 | |
N 6 months | 220 | 367 | 163 | |
N 12 months | 209 | 352 | 132 | |
N 18 months | 0 | 310 | 0 | |
N 24 months | 197 | 286 | 93 | |
N 36 months | 182 | 221 | 0 | |
Demographics | ||||
Female | 48 % | 36 % | 48 % | .003 |
Age (years), mean±SDa | 76.0±5.0 | 74.9±7.5 | 75.7±7.4 | <.001 |
Education (years), mean±SD | 16.0±2.9 | 15.7±3.0 | 14.7±3.2 | <.001 |
Any APOE ε4 alleles | 27 % | 54 % | 65 % | <.001 |
Baseline clinical data: mean ±SD | ||||
ADNI-EF | 0.70±0.67 | −0.03±0.77 | −0.86±0.80 | <.001 |
Category Fluency (Animals + Vegetables) | 34.6±8.1 | 26.7±7.3 | 20.5±7.5 | <.001 |
Clock Drawing | 4.7±0.6 | 4.2±1.0 | 3.5±1.3 | <.001 |
WAIS-R Digit Symbol | 45.7±10.2 | 36.9±11.2 | 27.5±12.4 | <.001 |
Digit Span Backwards | 7.4±2.2 | 6.2±2.0 | 5.0±1.8 | <.001 |
Trails A | 36.4±13.2 | 44.3±21.7 | 64.7±34.5 | <.001 |
Trails B | 89.2±44.3 | 131.0±73.5 | 198.0±86.9 | <.001 |
Trails B–Trails A | 52.8±38.8 | 86.7±63.3 | 133.6±75.1 | <.001 |
Baseline MRI datab | ||||
White matter hyperintensities (cm3) | 0.68±2.34 | 0.60±1.09 | 0.79±1.16 | 0.660 |
Cortical thicknesses (mm): | ||||
Caudal middle frontal | 2.3±0.2 | 2.2±0.2 | 2.2±0.2 | <.001 |
Rostral middle frontal | 2.2±0.1 | 2.1±0.2 | 2.1±0.2 | <.001 |
Superior middle frontal | 2.5±0.2 | 2.4±0.2 | 2.4±0.2 | <.001 |
Lateral orbito-frontal | 2.5±0.2 | 2.5±0.2 | 2.4±0.2 | <.001 |
Medial orbito-frontal | 2.3±0.1 | 2.3±0.2 | 2.2±0.2 | <.001 |
Pars-triangularis | 2.2±0.2 | 2.2±0.2 | 2.1±0.2 | <.001 |
N complete data for MRI measurements above |
152 | 216 | 77 | |
Baseline CSF datac | ||||
Total tau>93 pg/ml | 18 % | 44 % | 66 % | <.001 |
Aβ1-42<192 pg/ml | 38 % | 75 % | 90 % | <.001 |
PTau181P>23 pg/ml | 35 % | 70 % | 87 % | <.001 |
AD cluster | 36 % | 73 % | 94 % | <.001 |
N complete CSF data for CSF measurements above |
114 | 190 | 94 |
SD = Standard Deviation
Only MRI assessments with an overall quality control of “Pass” were included
Fisher’s exact test for categorical variables, ANOVA for continuous variables
Total protein (tau), beta amyloid 1-42 (Aβ1-42), and phosphorylated-tau protein 181 (pTau181p) dichotomized as in Shaw et al. 2009. AD Cluster from de Meyer et al. 2010