Table 1.

Demographic, clinical, CSF and MRI data by baseline diagnosis (n=800 with complete EF data)

	Normal	MCI	AD	p-valuec
Sample size
N Baseline	229	390	181
N 6 months	220	367	163
N 12 months	209	352	132
N 18 months	0	310	0
N 24 months	197	286	93
N 36 months	182	221	0
Demographics
Female	48 %	36 %	48 %	.003
Age (years), mean±SDa	76.0±5.0	74.9±7.5	75.7±7.4	<.001
Education (years), mean±SD	16.0±2.9	15.7±3.0	14.7±3.2	<.001
Any APOE ε4 alleles	27 %	54 %	65 %	<.001
Baseline clinical data: mean ±SD
ADNI-EF	0.70±0.67	−0.03±0.77	−0.86±0.80	<.001
Category Fluency (Animals + Vegetables)	34.6±8.1	26.7±7.3	20.5±7.5	<.001
Clock Drawing	4.7±0.6	4.2±1.0	3.5±1.3	<.001
WAIS-R Digit Symbol	45.7±10.2	36.9±11.2	27.5±12.4	<.001
Digit Span Backwards	7.4±2.2	6.2±2.0	5.0±1.8	<.001
Trails A	36.4±13.2	44.3±21.7	64.7±34.5	<.001
Trails B	89.2±44.3	131.0±73.5	198.0±86.9	<.001
Trails B–Trails A	52.8±38.8	86.7±63.3	133.6±75.1	<.001
Baseline MRI datab
White matter hyperintensities (cm3)	0.68±2.34	0.60±1.09	0.79±1.16	0.660
Cortical thicknesses (mm):
Caudal middle frontal	2.3±0.2	2.2±0.2	2.2±0.2	<.001
Rostral middle frontal	2.2±0.1	2.1±0.2	2.1±0.2	<.001
Superior middle frontal	2.5±0.2	2.4±0.2	2.4±0.2	<.001
Lateral orbito-frontal	2.5±0.2	2.5±0.2	2.4±0.2	<.001
Medial orbito-frontal	2.3±0.1	2.3±0.2	2.2±0.2	<.001
Pars-triangularis	2.2±0.2	2.2±0.2	2.1±0.2	<.001
N complete data for MRI   measurements above	152	216	77
Baseline CSF datac
Total tau>93 pg/ml	18 %	44 %	66 %	<.001
Aβ1-42<192 pg/ml	38 %	75 %	90 %	<.001
PTau181P>23 pg/ml	35 %	70 %	87 %	<.001
AD cluster	36 %	73 %	94 %	<.001
N complete CSF data for CSF   measurements above	114	190	94

^aSD = Standard Deviation

^bOnly MRI assessments with an overall quality control of “Pass” were included

^cFisher’s exact test for categorical variables, ANOVA for continuous variables

^dTotal protein (tau), beta amyloid 1-42 (Aβ_1-42), and phosphorylated-tau protein 181 (pTau_181p) dichotomized as in Shaw et al. 2009. AD Cluster from de Meyer et al. 2010